Regulation of the Microbiome-Endocannabinoidome axis in small intestine epithelial cells (Organoids). (Bénédicte Allam-Ndoul et Briscia Anaid Tinoco Mar)
Identifying the components of the endocannabinoid system and the mechanisms of mediation of exogenous and endogenous factors related to obesity (i.e. inflammation, intestinal microbiota, metabolites) involved in enteric homeostasis, insulin sensitivity and lipid metabolism.
Defining the sequence of events leading to gut dysfunction, peripheral, central and metabolic alterations during diet-induced obesity development in mice (GUT-IR). (Florent Pechereau and Gabrielle St-Arnaud)
Establishing the chronological relationship between enteric insulin resistance state, small intestine dysfunctions, and the microbiome-endocannabinoidome axis in the context of metabolic complications associated with obesity and type 2 diabetes.
The influence of host environmental factors on the gut microbiome-endocannabinoidome axis in metabolic and mental health (eMECA). (Sophie Castonguay-Paradis and Isabelle Bourdeau-Julien)
Investigate the interplay of the microbiome-endocannabinoidome axis with host environmental factors and intestinal, metabolic and mental health status in a cohort of free-living volunteers with various body composition, dietary habits and daily physical activity levels.
Production of metabolites derived from the microbiota in response to the Mediterranean diet (META). (Sophie Castonguay-Paradis et Isabelle Bourdeau-Julien)
Establish the contribution of the gut microbiota to metabolites production in response to a short-term, 2-day Mediterranean diet intervention. Gut microbiota composition and functions are the key determinants of interindividual variability in the endocannabinoidome and the production of metabolites from precursor nutrients typical of the Mediterranean diet.
Evaluation of the impact of probiotic strains on the microbiome-endocannabinoidome axis in a preclinical and clinical intervention model. (Sophie Castonguay-Paradis)
Projet en cours. Détails à venir.