Dr. Veilleux and his team explore the factors and mechanisms of the intestinal microenvironment involved in the disruption of intestinal functions and leading to the development of metabolic alterations in obese insulin-resistant or diabetic individuals. Discover the projects that motivate them on a daily basis!
Identifying the components of the endocannabinoid system and the mechanisms of mediation of exogenous and endogenous factors related to obesity (i.e. inflammation, intestinal microbiota, metabolites) involved in enteric homeostasis, insulin sensitivity and lipid metabolism.
Establishing the chronological relationship between enteric insulin resistance state, small intestine dysfunctions, and the microbiome-endocannabinoidome axis in the context of metabolic complications associated with obesity and type 2 diabetes.
Investigate the interplay of the microbiome-endocannabinoidome axis with host environmental factors and intestinal, metabolic and mental health status in a cohort of free-living volunteers with various body composition, dietary habits and daily physical activity levels.
Establish the contribution of the gut microbiota to metabolites production in response to a short-term, 2-day Mediterranean diet intervention. Gut microbiota composition and functions are the key determinants of interindividual variability in the endocannabinoidome and the production of metabolites from precursor nutrients typical of the Mediterranean diet.