Publications scientifiques | Chaire d’excellence en recherche du Canada sur l’axe microbiome-endocannabinoïdome dans la santé métabolique

A sustainable protocol for the synthesis of N-acyl tryptamines, a class of potential gut microbiota-derived endocannabinoid-like mediators.
Villano R, Di Marzo V. Front Chem. 2024 Oct 10;12:1436008. doi: 10.3389/fchem.2024.1436008. PMID: 39449691; PMCID: PMC11500036.
Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis.
Dubbioso R, Iannotti FA, Senerchia G, et al. Eur J Neurol. 2024 Aug 16:e16400. doi: 10.1111/ene.16400. Epub ahead of print. PMID: 39152573.
The human fecal endocannabinoidome mediator profile is mainly defined by the fecal microbiota and diet.
Castonguay-Paradis S, Parent L, St-Arnaud G, et al. J Clin Endocrinol Metab. 2024 Aug 22:dgae586. doi: 10.1210/clinem/dgae586. Epub ahead of print. PMID: 39171571.
Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study.
Mboumba Bouassa RS, Giorgini G, Silvestri C, et al. iScience. 2024 Jul 5;27(8):110456. doi: 10.1016/j.isci.2024.110456. PMID: 39156649; PMCID: PMC11326910.
Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication.
Villano R, Di Marzo V. Molecules. 2024 Aug 5;29(15):3703. doi: 10.3390/molecules29153703. PMID: 39125106; PMCID: PMC11313728.
The Impact of the CB₂ Cannabinoid Receptor in Inflammatory Diseases: An Update.
Rakotoarivelo V, Mayer TZ, Simard M, et al. Molecules. 2024 Jul 18;29(14):3381. doi: 10.3390/molecules29143381. PMID: 39064959; PMCID: PMC11279428.
The short-chain fatty acid acetate modulates orexin/hypocretin neurons: A novel mechanism in gut-brain axis regulation of energy homeostasis and feeding.
Forte N, Marfella B, Nicois A, et al. Biochem Pharmacol. 2024 Jun 20;226:116383. doi: 10.1016/j.bcp.2024.116383. Epub ahead of print. PMID: 38908530.
The human milk endocannabinoidome and neonatal growth in gestational diabetes.
Fradet A, Castonguay-Paradis S, Dugas C, et al. Front Endocrinol (Lausanne). 2024 Jun 13;15:1415630. doi: 10.3389/fendo.2024.1415630. PMID: 38938519; PMCID: PMC11208692.
Human gut microbiota and their production of endocannabinoid-like mediators are directly affected by a dietary oil.
Roussel C, Sola M, Lessard-Lord J, et al. Gut Microbes. 2024 Jan-Dec;16(1):2335879. doi: 10.1080/19490976.2024.2335879. Epub 2024 May 2. PMID: 38695302; PMCID: PMC11067990.
PEA-OXA restores cognitive impairments associated with vitamin D deficiency-dependent alterations of the gut microbiota.
Guida F, Iannotta M, Perrone M, et al. Biomed Pharmacother. 2024 Apr 25;175:116600. doi: 10.1016/j.biopha.2024.116600. Epub ahead of print. PMID: 38670046.
Investigating the alterations of endocannabinoidome signaling in the human small intestine in the context of obesity and type 2 diabetes.
Rakotoarivelo V, Allam-Ndoul B, Martin C, et al. Heliyon. 2024 Mar 2;10(6):e26968. doi: 10.1016/j.heliyon.2024.e26968. PMID: 38515705; PMCID: PMC10955212.
Pharmacological evidences that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils.
Lavoie JC, Simard M, Kalkan H, et al. J Leukoc Biol. 2024 Feb 12:qiae029. doi: 10.1093/jleuko/qiae029. Epub ahead of print. PMID: 38345417.
Mathematical modeling of fluid dynamics in in vitro gut fermentation systems: A new tool to improve the interpretation of microbial metabolism.
Lessard-Lord J, Lupien-Meilleur J, Roussel C, et al. FASEB J. 2024 Jan 31;38(2):e23398. doi: 10.1096/fj.202301739RR. PMID: 38214938.
Effect of a Probiotic Beverage Enriched with Cricket Proteins on the Gut Microbiota: Composition of Gut and Correlation with Nutritional Parameters.
Dridi C, Millette M, Salmieri S, et al. Foods. 2024 Jan 9;13(2):204. doi: 10.3390/foods13020204. PMID: 38254505; PMCID: PMC10814958.
Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.
Lopez-Cortes OD, Trujillo-Sánchez F, Sierra-Ruelas E, et al. Int J Obes (Lond). 2023 Dec 19. doi: 10.1038/s41366-023-01428-9. Epub ahead of print. PMID: 38114812.
Dietary food patterns as determinants of the gut microbiome-endocannabinoidome axis in humans.
Castonguay-Paradis S, Perron J, Flamand N, et al. Sci Rep. 2023 Sep 21;13(1):15702. doi: 10.1038/s41598-023-41650-z. PMID: 37735572; PMCID: PMC10514042.
Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity.
Forte N, Roussel C, Marfella B, et al. Commun Biol. 2023 Sep 21;6(1):959. doi: 10.1038/s42003-023-05295-y. PMID: 37735539; PMCID: PMC10514336.
New role for the anandamide metabolite prostaglandin F_2α ethanolamide: Rolling preadipocyte proliferation.
Boubertakh B, Courtemanche O, Marsolais D, et al. J Lipid Res. 2023 Sep 18:100444. doi: 10.1016/j.jlr.2023.100444. Epub ahead of print. PMID: 37730163.
Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin.
Kalkan H, Panza E, Pagano E, et al. Cell Death Dis. 2023 Aug 23;14(8):544. doi: 10.1038/s41419-023-06080-9. PMID: 37612317; PMCID: PMC10447569.
FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.
Sierra-Ruelas E, Torres-Castillo N, Vizmanos B, et al. Metab Syndr Relat Disord. 2023 Jul 11. doi: 10.1089/met.2023.0014. Epub ahead of print. PMID: 37433211.
Gene-based microbiome representation enhances host phenotype classification.
Deschênes T, Tohoundjona FWE, Plante PL, et al. mSystems. 2023 Jul 5:e0053123. doi: 10.1128/msystems.00531-23. Epub ahead of print. PMID: 37404032.
The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders.
Mir HD, Giorgini G, Di Marzo V. Psychoneuroendocrinology. 2023 May 18;154:106295. doi: 10.1016/j.psyneuen.2023.106295. Epub ahead of print. PMID: 37229916.
Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice.
Venneri T, Giorgini G, Leblanc N, et al. Lipids Health Dis. 2023 May 15;22(1):63. doi: 10.1186/s12944-023-01823-1. PMID: 37189092; PMCID: PMC10186685.
Hypoabsorptive surgeries cause limb-dependent changes in the gut endocannabinoidome and microbiome in association with beneficial metabolic effects.
Mukorako P, St-Pierre DH, Flamand N, et al. Int J Obes (Lond). 2023 May 4. doi: 10.1038/s41366-023-01307-3. Epub ahead of print. PMID: 37142736.
The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior.
Silvestri C, Di Marzo V. Function (Oxf). 2023 Jan 12;4(2):zqad003. doi: 10.1093/function/zqad003. PMID: 36778747; PMCID: PMC9909364.
Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders.
Daniel N, Le Barz M, Mitchell PL, et al. Function (Oxf). 2022 Dec 29;4(2):zqac069. doi: 10.1093/function/zqac069. PMID: 36778746; PMCID: PMC9909367.
The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population. Microbiome.
Bourdeau-Julien I, Castonguay-Paradis S, Rochefort G, et al. 2023 Feb 11;11(1):26. doi: 10.1186/s40168-023-01469-2. PMID: 36774515.
A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota.
Suriano F, Manca C, Flamand N, et al.. Cells. 2023 Jan 25;12(3):411. doi: 10.3390/cells12030411. PMID: 36766753.
Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples.
Falascina G, Bindels LB, Di Marzo V, Cutignano A. J Pharm Biomed Anal. 2023 Jan 13;226:115252. doi: 10.1016/j.jpba.2023.115252. Epub ahead of print. PMID: 36657348.
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy.
Kalkan H, Pagano E, Paris D, et al. EMBO Mol Med. 2023 Jan 3:e16225. doi: 10.15252/emmm.202216225. Epub ahead of print. PMID: 36594243.
Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice.
Guevara Agudelo FA, Leblanc N, Bourdeau-Julien I, et al. Front Immunol. 2022 Nov 11;13:1028412. doi: 10.3389/fimmu.2022.1028412. PMID: 36439185; PMCID: PMC9692131.
Gestational Diabetes Mellitus, Human Milk Composition, and Infant Growth.
Dugas C, Laberee L, Perron J, et al. Breastfeed Med. 2022 Nov 21. doi: 10.1089/bfm.2022.0085. Epub ahead of print. PMID: 36409543.
Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome.
Inserra A, Giorgini G, Lacroix S, et al. Br J Pharmacol. 2022 Oct 31. doi: 10.1111/bph.15977. Epub ahead of print. PMID: 36316276.
Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed.
Ben Necib R, Manca C, Lacroix S, et al. Front Immunol. 2022 Sep 26;13:882455. doi: 10.3389/fimmu.2022.882455. PMID: 36238310; PMCID: PMC9552265.
Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families.
Simard M, Archambault AS, Lavoie JC, et al. Biochem Pharmacol. 2022 Sep 21;205:115261. doi: 10.1016/j.bcp.2022.115261. Epub ahead of print. PMID: 36152677.
Short-term supplementation with ω-3 polyunsaturated fatty acids modulates primarily mucolytic species from the gut luminal mucin niche in a human fermentation system.
Roussel C, Anunciação Braga Guebara S, Plante PL, et al. Gut Microbes. 2022 Jan-Dec;14(1):2120344. doi: 10.1080/19490976.2022.2120344. PMID: 36109831.
Cannabinoids and Chronic Liver Diseases.
Mboumba Bouassa RS, Sebastiani G, Di Marzo V, et al. Int J Mol Sci. 2022 Aug 20;23(16):9423. doi: 10.3390/ijms23169423. PMID: 36012687; PMCID: PMC9408890.
Obesity: The Fat Tissue Disease Version of Cancer.
Boubertakh B, Silvestri C, Di Marzo V. Cells. 2022 Jun 9;11(12):1872. doi: 10.3390/cells11121872. PMID: 35741001; PMCID: PMC9221301.
Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study.
Forteza F, Bourdeau-Julien I, Nguyen GQ, et al. Sci Rep. 2022 May 20;12(1):8568. doi: 10.1038/s41598-022-10757-0. PMID: 35595747; PMCID: PMC9122896.
Facile and Sustainable Synthesis of Commendamide and its Analogues.
Villano R, Tinto F, Di Marzo V. Front Chem. 2022 Mar 1;10:858854. doi: 10.3389/fchem.2022.858854. PMID: 35300384; PMCID: PMC8921460.
Expression and Functions of the CB₂ Receptor in Human Leukocytes.
Simard M, Rakotoarivelo V, Di Marzo V and Flamand N (2022) Front. Pharmacol. 13:826400. doi: 10.3389/fphar.2022.826400
Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint.
Animals (Basel). Schiano Moriello A, Di Marzo V, Petrosino S. 2022 Jan 31;12(3):348. doi: 10.3390/ani12030348. PMID: 35158670; PMCID: PMC8833664.
(Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders.
Sihag J, Di Marzo V. Lipids Health Dis. 2022 Jan 14;21(1):9. doi: 10.1186/s12944-021-01609-3. PMID: 35027074; PMCID: PMC8759188.
Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners.
Archambault AS, Brassard J, Bernatchez É, et al. Cells. 2022 Jan 2;11(1):141. doi: 10.3390/cells11010141. PMID: 35011703.
Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
Suriano F, Manca C, Flamand N, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jan;1867(1):159056. doi: 10.1016/j.bbalip.2021.159056. Epub 2021 Oct 1. PMID: 34606993.
Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome.
Shen M, Manca C, Suriano F, et al. Molecules. 2021 Dec 21;27(1):1. doi: 10.3390/molecules27010001. PMID: 35011234.
Effect of Docosahexaenoic Acid (DHA) at the Enteric Level in a Synucleinopathy Mouse Model.
Lamontagne-Proulx J, Coulombe K, Dahhani F, et al. Nutrients. 2021 Nov 24;13(12):4218. doi: 10.3390/nu13124218. PMID: 34959768; PMCID: PMC8703327.
α-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model.
Simard M, Tremblay A, Morin S, et al. Acta Biomater. 2021 Nov 20:S1742-7061(21)00770-4. doi: 10.1016/j.actbio.2021.11.021. Epub ahead of print. PMID: 34808417.
Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis.
Abolghasemi A, Manca C, Iannotti FA, et al. Int J Mol Sci. 2021 Nov 16;22(22):12361. doi: 10.3390/ijms222212361. PMID: 34830242; PMCID: PMC8620071.
Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.
Forte N, Boccella S, Tunisi L, et al. Nat Commun. 2021 Oct 21;12(1):6137. doi: 10.1038/s41467-021-26388-4. PMID: 34675233; PMCID: PMC8531398.
Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers.
Isaac AR, de Velasco PC, Fraga KYD, et al. J Nutr Biochem. 2021 Oct;96:108782. doi: 10.1016/j.jnutbio.2021.108782. Epub 2021 May 24. PMID: 34038760.
Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity.
Manca C, Lacroix S, Pérusse F, et al. Biomedicines. 2021 Sep 17;9(9):1246. doi: 10.3390/biomedicines9091246. PMID: 34572432; PMCID: PMC8471891.
Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators.
Ayoub SM, Piscitelli F, Silvestri C, et al. Front Pharmacol. 2021 Sep 15;12:706703. doi: 10.3389/fphar.2021.706703. PMID: 34603019; PMCID: PMC8479102.
Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.
Archambault AS, Tinto F, Dumais É, et al. Cells. 2021 Sep 5;10(9):2322. doi: 10.3390/cells10092322. PMID: 34571971; PMCID: PMC8470279.
Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva.
Tinto F, Archambault AS, Dumais É, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158954. doi: 10.1016/j.bbalip.2021.158954. Epub 2021 Apr 27. PMID: 33915294.
Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19.
Zaid Y, Doré É, Dubuc I, et al. J Allergy Clin Immunol. 2021 Aug;148(2):368-380.e3. doi: 10.1016/j.jaci.2021.05.032. Epub 2021 Jun 7. PMID: 34111453; PMCID: PMC8180473.
Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.
Vitale RM, Iannotti FA, Schiano Moriello A, et al. Biomolecules. 2021 Aug 1;11(8):1134. doi: 10.3390/biom11081134. PMID: 34439801; PMCID: PMC8394412.
High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients.
Archambault AS, Zaid Y, Rakotoarivelo V, et al. FASEB J. 2021 Jun;35(6):e21666. doi: 10.1096/fj.202100540R. PMID: 34033145; PMCID: PMC8206770.
Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism.
Rakotoarivelo V, Sihag J, Flamand N. Cells. 2021 May 21;10(6):1279. doi: 10.3390/cells10061279. PMID: 34064024; PMCID: PMC8224009.
Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome.
Forteza F, Giorgini G, Raymond F. Cells. 2021 Apr 17;10(4):938. doi: 10.3390/cells10040938. PMID: 33920695; PMCID: PMC8072750.
A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator.
Manzo E, Schiano Moriello A, Tinto F, et al. Cells. 2021 Feb 20;10(2):450. doi: 10.3390/cells10020450. PMID: 33672574; PMCID: PMC7924038.
Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice.
Tunisi L, D'Angelo L, Fernández-Rilo AC, et al. Front Synaptic Neurosci. 2021 Feb 4;13:622405. doi: 10.3389/fnsyn.2021.622405. PMID: 33613258; PMCID: PMC7890184.
The gut microbiome, endocannabinoids and metabolic disorders.
Iannotti FA, Di Marzo V. J Endocrinol. 2021 Feb;248(2):R83-R97. doi: 10.1530/JOE-20-0444. PMID: 33337346.
Genomic diversity and CRISPR-Cas systems in the cyanobacterium Nostoc in the High Arctic
Jungblut, AD., Raymond, F., Dion, MB., et al. Environ Microbiol. 2021 Mar 24. doi: 10.1111/1462-2920.15481. Epub ahead of print. PMID: 33760341.
Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists
Depommier, C., Vitale, R.M., Iannotti, F.A., et al.Cells 2021, 10, 185. https://doi.org/10.3390/cells10010185
Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models
Depommier C, Flamand N, Pelicaen R,. Cells. 2021; 10(1):71. https://doi.org/10.3390/cells10010071
N-palmitoyl-D-glucosamine, A Natural Monosaccharide-Based Glycolipid, Inhibits TLR4 and Prevents LPS-Induced Inflammation and Neuropathic Pain in Mice
Iannotta M, Belardo C, Trotta MC, et al. International Journal of Molecular Sciences. 2021; 22(3):1491. https://doi.org/10.3390/ijms22031491
Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota
Dione, N., Lacroix, S., Taschler, U., et al. Cells 2020, 9, 2705. https://doi.org/10.3390/cells9122705
Alterations of brain endocannabinoidome signaling in germ-free mice
Manca, C., Shen, M., Boubertakh, B., et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec;1865(12):158786. doi: 10.1016/j.bbalip.2020.158786. Epub 2020 Aug 11.PMID: 32795503
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
Ruocco, C., Ragni, M., Rossi, F., et al. Diabetes. 2020 Nov;69(11):2324-2339. doi: 10.2337/db20-0489. Epub 2020 Aug 10. PMID: 32778569
Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis
Silvestri, C., Pagano, E., Lacroix, S., et al. Front. Pharmacol., 08 October 2020 | https://doi.org/10.3389/fphar.2020.585096
Intuitive eating is associated with elevated levels of circulating omega-3 polyunsaturated fatty acid-derived endocannabinoidome mediators
Rochefort, G., Provencher, V., Castonguay-Paradis, S., et al. Appetite. 2020; https://doi.org/10.1016/j.appet.2020.104973
Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat
Castonguay-Paradis, S., Lacroix, S., Rochefort, G., et al. Sci Rep 10, 15975 (2020). https://doi.org/10.1038/s41598-020-72861-3
Gut Microbiota and Intestinal Trans-Epithelial Permeability
Allam-Ndoul, B.; Castonguay-Paradis, S.; Veilleux, A. Int. J. Mol. Sci. 2020, 21, 6402.
Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism
Lefort C, Roumain M, Van Hul M., et al. Cells. 2020; 9(5):1247. https://doi.org/10.3390/cells9051247
Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain
Guida F, Boccella S, Belardo C, et al. Brain Behav Immun. 2020 Mar;85:128-141. doi: 10.1016/j.bbi.2019.04.006. Epub 2019 Apr 3. PMID: 30953765.
Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2‐arachidonoyl‐glycerol and its congeners in human myeloid leukocytes
Turcotte, C., Archambault, AS., Dumais, É., et al. The FASEB Journal. 2020; 34: 4253– 4265. https://doi.org/10.1096/fj.201902916R
Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling
Manca, C., Boubertakh, B., Leblanc, N., et al. J. Lipid Res. 2020; 61:(1) 70-85. First Published on November 5, 2019, doi:10.1194/jlr.RA119000424
Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome
Di Marzo, V., Silvestri, C. Nutrients. 2019 Aug 20;11(8):1956. doi: 10.3390/nu11081956. PMID: 31434293; PMCID: PMC6722643.
Role of the Endocannabinoidome in Human and Mouse Atherosclerosis
Piscitelli, F., Silvestri, C.Curr Pharm Des. 2019;25(29):3147-3164. doi: 10.2174/1381612825666190826162735. PMID: 31448709.
The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus
Veilleux, A., Di Marzo, V. & Silvestri, C. Curr Diab Rep 19, 117 (2019). https://doi.org/10.1007/s11892-019-1248-9. Current diabetes reports 19 (11), 117
Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice
Lacroix, S., Pechereau, F., Leblanc, N., et al. mSystems. 2019; 4 (6), doi: 10.1128/mSystems.00407-19
Human leukocytes differentially express endocannabinoid‐glycerol lipases and hydrolyze 2‐arachidonoyl‐glycerol and its metabolites from the 15‐lipoxygenase and cyclooxygenase pathways
Turcotte, C., Dumais, É., Archambault, AS., et al. Journal of leukocyte biology. 2019; 106 (6), 1337-1347
20‐Hydroxy‐ and 20‐carboxy‐leukotriene (LT) B4 downregulate LTB4‐mediated responses of human neutrophils and eosinophils
Archambault, AS., Poirier, S., Lefebvre, JS., et al. Journal of leukocyte biology. 2019; 105 (6), 1131-1142, doi : https://doi.org/10.1002/JLB.3A0919-049RRR
Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
Everard, A., Plovier, H., Rastelli, M. et al. Nat Commun 10, 457 (2019). https://doi.org/10.1038/s41467-018-08051-7
The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients
Pagano E, Romano B, Iannotti FA, et al. Pharmacological Research. 2019 Nov;149:104464. DOI: 10.1016/j.phrs.2019.104464.
Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
Tunisi L, Forte N, Fernández-Rilo AC, et al. Front. Endocrinol. 2019; 10:219. doi: 10.3389/fendo.2019.00219
Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils
Archambault, AS., Turcotte, C., Martin, C., et al. PloS one. 2018; 13 (8), doi: 10.1371/journal.pone.0202424
Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists
Schiano Moriello A, López Chinarro S, Novo Fernández O, et al. J Med Chem. 2018 Sep 27;61(18):8255-8281. doi: 10.1021/acs.jmedchem.8b00734. Epub 2018 Sep 14. PMID: 30176215.
Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice
Guida F, Turco F, Iannotta M, et al. Brain Behav Immun. 2018 Jan;67:230-245. doi: 10.1016/j.bbi.2017.09.001. Epub 2017 Sep 7. PMID: 28890155.

Publications scientifiques de la Chaire